The skin as a critical window in unveiling the pathophysiologic principles of COVID-19.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), is a single-stranded RNA virus whose sequence is known. COVID-19 is associated with a heterogeneous clinical phenotype ranging from asymptomatic to fatal disease. It appears that access to nasopharyngeal respiratory epithelia expressing angiotensin-converting enzyme (ACE) 2, the receptor for SARS-CoV-2, is followed by viral replication in the pulmonary alveolar septal capilla...
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The histologic and molecular correlates of COVID-19 vaccine-induced changes in the skin.

A total of 22 patients who had developed an adverse cutaneous reaction to the Moderna or Pfizer vaccine underwent biopsies. Each patient was assessed light microscopically, and, in select biopsies, spike glycoprotein and cytokine assessment were also conducted. The patients developed self-limited cutaneous reactions often described clinically as urticarial or eczematous within 1 day to 4 weeks after receiving the first or second dose of the Pfizer or Moderna vaccine. Read more: https://pubmed.nc...
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Histopathology of sabra dermatitis: A case report

Sabra dermatitis (SD) is a form of irritant contact dermatitis caused by penetration of small, hair-like glochids from Opuntia cactus into the skin. SD is a common problem among the farmers who are in close contact with prickly pears; however, the histopathologic criteria for this condition are not well defined. The purpose of this article is to present a well-documented case of SD and to acquaint pathologists with the entity. Source: https://pubmed.ncbi.nlm.nih.gov/31033007/...
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