News & Publications

Pathology Laboratory Associates, Inc. (PLA) is an independent physician owned pathology group. PLA has proudly served physicians and patients in Oklahoma, Kansas, Missouri, and across the United States for over 40 years. The PLA headquarters and full-service anatomic and molecular pathology laboratory is located in Tulsa, Oklahoma.

Publications
Neil Crowson

The skin as a critical window in unveiling the pathophysiologic principles of COVID-19.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), is a single-stranded RNA virus whose sequence is known. COVID-19 is associated with a heterogeneous clinical phenotype ranging from asymptomatic to fatal disease. It appears that access to nasopharyngeal respiratory epithelia expressing angiotensin-converting enzyme (ACE) 2, the receptor for SARS-CoV-2, is followed by viral replication in the pulmonary alveolar septal capillary bed. We have demonstrated in earlier studies that incomplete viral particles, termed pseudovirions, dock to deep subcutaneous and other vascular beds, potentially contributing to the prothrombotic state and systemic complement activation that characterizes severe and critical COVID-19. Read more: https://pubmed.ncbi.nlm.nih.gov/34920833/

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Publications
Neil Crowson

Premortem Skin Biopsy Assessing Microthrombi, Interferon Type I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage

Apart from autopsy, tissue correlates of coronavirus disease 2019 (COVID-19) clinical stage are lacking. In the current study, cutaneous punch biopsy specimens of 15 individuals with severe/critical COVID-19 and six with mild/moderate COVID-19 were examined. Evidence for arterial and venous microthrombi, deposition of C5b-9 and MASP2 (representative of alternative and lectin complement pathways, respectively), and differential expression of interferon type I-driven antiviral protein MxA (myxovirus resistance A) versus SIN3A, a promoter of interferon type I-based proinflammatory signaling, were assessed. Control subjects included nine patients with sepsis-related acute respiratory distress syndrome (ARDS) and/or acute kidney injury (AKI) pre-COVID-19.  Read the full publication: https://pubmed.ncbi.nlm.nih.gov/35640675/

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Publications
Neil Crowson

The histologic and molecular correlates of COVID-19 vaccine-induced changes in the skin.

A total of 22 patients who had developed an adverse cutaneous reaction to the Moderna or Pfizer vaccine underwent biopsies. Each patient was assessed light microscopically, and, in select biopsies, spike glycoprotein and cytokine assessment were also conducted. The patients developed self-limited cutaneous reactions often described clinically as urticarial or eczematous within 1 day to 4 weeks after receiving the first or second dose of the Pfizer or Moderna vaccine. Read more: https://pubmed.ncbi.nlm.nih.gov/34920834/

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Publications
Neil Crowson

Severe COVID-19: A multifaceted viral vasculopathy syndrome

The objective of this study was to elucidate the pathophysiology that underlies severe COVID-19 by assessing the histopathology and the in situ detection of infectious SARS-CoV-2 and viral capsid proteins along with the cellular target(s) and host response from twelve autopsies. Read more: https://pubmed.ncbi.nlm.nih.gov/33248385/

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Publications
Neil Crowson

Docked severe acute respiratory syndrome coronavirus 2 proteins within the cutaneous and subcutaneous microvasculature and their role in the pathogenesis of severe coronavirus disease 2019

The purpose of this study was to examine the deltoid skin biopsy in twenty-three patients with coronavirus disease 2019 (COVID-19), most severely ill, for vascular complement deposition and correlate this with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA and protein localization and ACE2 expression.  Read more: https://pubmed.ncbi.nlm.nih.gov/33058948/

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Publications
Neil Crowson

Histopathology of sabra dermatitis: A case report

Sabra dermatitis (SD) is a form of irritant contact dermatitis caused by penetration of small, hair-like glochids from Opuntia cactus into the skin. SD is a common problem among the farmers who are in close contact with prickly pears; however, the histopathologic criteria for this condition are not well defined. The purpose of this article is to present a well-documented case of SD and to acquaint pathologists with the entity. Source: https://pubmed.ncbi.nlm.nih.gov/31033007/

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Publications
Neil Crowson

Data warehouse strategies and the modern anatomic pathology laboratory: Quality management, patient safety, and pathology productivity issues and opportunities

Application of lean process management strategies to process improvement in clinical and anatomic pathology laboratories afford opportunities to enhance workflow process to lower costs and simultaneously to improve patient safety. Bar-codes are now employed in most modern anatomic pathology laboratories to track specimens from the clinicians’ office or the operating room all through the continuum of service to specimen disposal. Read more: https://pubmed.ncbi.nlm.nih.gov/31227427/

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Publications
Neil Crowson

Folliculocentric Herpes: A Clinicopathological Study of 28 Patients

The cutaneous manifestations of herpes infection are primarily in the context of active infection and of the post-herpetic zosteriform eruption. The former manifests cytopathic alterations diagnostic of herpes. The latter includes lichen planus-like and granuloma annulare-like eruptions and lymphocytoma cutis. Read more: https://pubmed.ncbi.nlm.nih.gov/27149333/

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